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Dr. A.J.Halim

Dr. A.J.Halim

Lincoln University College Consultant Pediatrician, KPJ Ampang Puteri Specialist

Title: Prevention of kidney diseases through a Systems Biology approach

Biography

Biography: Dr. A.J.Halim

Abstract

The key to preventing kidney diseases is in maintaining the body regulatory mechanisms in an optimum physiological state.  Cellular functions are sensitive to the state of the EXTRACELLULAR  MATRIX.  Genetic and epigenetic factors interact in a myriad of ways  to control cell phenotype through cell-matrix interactions thereby leading to a healthy or disease state.   Each patient is unique in his/her physical, mental,  social and psychospiritual domains,  his environment and  his lifestyle.  The  world we live in has changed so much with  unprecedented environmental degradation,  pollution, agricultural food production methods,  xenobiotics in  animal husbandry and endocrine disrupting chemicals,  all contributing  to  dysfunctions in our body regulatory systems. The unbalanced external ecological system reflects  itself in our own inner ecosystem,  disrupting our immunological, endocrine and  neurological systems.  All these compounded by emotional and physical stresses  lead to  poorer  cellular health and vitality.  The objective of  classical cell therapy has always been the enfreshment/restoration of the functional capability of the cells and their functional associates, the tissues and organs. It aims at producing a state of health thereby eliminating symptoms.  In the Genomic era today, we see the possibility of using genomics,  epigenomics,  transcriptomics, proteomics, metabolomics, microbiomics (multi  -omics) to  provide biomarkers for prevention, ill health and healing.  This is an exciting  scientific development.  A more integrative approach to medicine  and research  is imperative where positive outcomes of treatment are studied in the  context of systems biology to find ways to correct the identifiable pathway perturbations thereby leading to  treatment.  The speaker will discuss management  of kidney disorders with fetal precursor stem cell transplantation and the preparatory protocol to achieve the best possible state of the  extracellular matrix.  He will touch on the  role of microbiome, nutrients, lifestyle, environmental  and psychospiritual factors in influencing phenotypic expression through epigenetic mechanisms.