Jose L Reyes
National Polytechnic Institute, Mexico
Title: Early alterations in diabetic nephropathy
Biography
Biography: Jose L Reyes
Abstract
Diabetes is one of the main causes of renal failure all over the world. The mechanisms initiating diabetic nephropathy have been only partially studied. We analyzed the damage induced by diabetes on the intercellular renal junctions since information on this issue is relevant. Glucose is filtered in the kidney at the glomeruli and is reabsorbed at the proximal tubule. In the absorption of glucose participates SGLT1 and 2, located at the apical brush border and GLUT1 and 2, located at the basolateral membrane of the proximal tubular cells. We explored differentially alterations in the glomeruli, the proximal tubule and the distal tubule. We found extensive decrease and damage in claudin 5, protein located at the glomerular capillaries and in claudin 2, intercellular protein of the proximal tubule. In distal tubules we found increment in claudins 4 and 8, but not delocalization of these proteins. These lesions were observed in the presence of oxidative stress which has been also described in the diabetic patient. The glomerular and the proximal tubular damage were ameliorated by the prevention of oxidative stress.