Glenda C Gobe
University of Queensland, Australia
Title: Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease
Biography
Biography: Glenda C Gobe
Abstract
Oxidative stress is implicated in progression and development of chronic kidney disease (CKD). This study sought to investigate the effects of a 12-month (12-mo) exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis CKD patients. 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with or without a lifestyle intervention (multidisciplinary care clinic, a lifestyle program, and aerobic and resistance exercise training) for 12-mo. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12-mo. We found there were no significant differences between groups (64 in standard care and 72 in lifestyle intervention) at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (35.2±117.8 pg/mL versus 26.9±146.6 pg/ml; p=0.88), GPX (5.0±4.1 U/L versus 5.3±6.0 U/L; p=0.87), or TAC (-0.03±0.1 versus -0.05±0.2; p=0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention (-106.2±157.8 pg/mL) compared to standard care (-38.1±81.6 pg/mL) (p=0.06). There was no difference in the change in eGFR between standard care (-0.2±7.8 mL/min/1.73m2) and lifestyle intervention (-1.6±6.7 mL/min/1.73m2) (p=0.33). In conclusion, exercise and lifestyle modification in stage 3-4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-mo period. However patients with high IsoP may benefit most from the addition of intervention to standard care.