Kai Song
Soochow University School of Medicine, China
Title: Hydrogen sulfide inhibits the renal fibrosis of chronic kidney disease
Biography
Biography: Kai Song
Abstract
Hydrogen sulfide (H2S) represents the third gasotransmitter along with nitric oxide and carbon monoxide. Recently it has been found that H2S levels was decreased in chronic kidney disease, but its physiological functions in kidney have not been fully elucidated. Previous work demonstrate that H2S has diuretic, natriuretic, and kaliuretic properties. It can also increase glomerular filtration rate and functions as an oxygen sensor in the renal medulla. Using the rat model of unilateral ureteral obstruction, we verified that cystathionine-β-synthase was the dominant H2S-producing enzyme located in renal tubular while another H2S-generating enzyme cystathionine-γ-lyase was mainly expressed in glomeruli. Administration with 56μg/kg.d sodium hydrogensulfide (a H2S donor) inhibited renal fibrosis by attenuating the production of collagen, extracellular matrix, and the expression of a-smooth muscle actin. The underlying mechanisms were associated with the anti-inflammation effect of H2S as well as its anti-proliferative and anti-differentiation properties on renal fibroblasts. Using a rate model of peritoneal fibrosis, our current data also confirmed that H2S was able to improved the peritoneal function and inhibits peritoneal fibrosis caused by peritoneal dialysis solution. Thus, low doses of H2S or its releasing compounds may have therapeutic potentials in treating chronic kidney disease.