Nephrology & Therapeutics

Biography

Biography: Itagores Hoffman

Abstract

Introduction: Screening for chronic kidney disease (CKD) has been advocated with increasing frequency. Population-based studies relating to the prevalence of CKD in the community are limited. We prospectively studied whether stratification by SCORED values could be useful in identifying subjects who are at high-risk for CKD in a general population-based sample. Methods: The frequency of individuals at high-risk for CKD was determined using a cross-sectional study of 873 adult households in Palmas, Brazil, that were randomly selected using a stratified, cluster method. Age, gender, and race of the study sample were similar to the population of Palmas. Results: An estimated GFR <60ml/min/1.73 m2 was present in 46(5.3%) of the participants studied, and the risk of CKD was greater in women than in men, and increased with age from 2.7% in the 18-44 age group to 19.0% in those ≥65 years. The frequencies of CKD Stage 3, 4 and 5 were 4.8%, 0.5%, and 0%, respectively. The SCORED values included 224 (25.7%) patients with high SCORED values (≥4), and 649(74.3%) subjects with low SCORED values. The subjects with higher SCORED values were at a significantly higher risk for CKD compared with those who had lower SCORED values (12.9% vs. 2.6%, χ2=35.58; p<0.001). Sensivity, specificity and negative predictive value for predicting CKD by the SCORED model was 63%, 76%, and 76%, respectively.
 Conclusion: High SCORED values were associated with a higher risk for CKD in a general population-based sampling. This simple screening tool was useful in identifying individuals at high-risk for CKD.