Malgorzata Karbowska
Medical University of Bialystok, Poland
Title: Indoxyl sulfate modulates the activity of coagulation system and fibrinolysis in animal model of experimental arterial thrombosis
Biography
Biography: Malgorzata Karbowska
Abstract
Objective: Chronic kidney disease (CKD) is associated with higher risk for thromboembolic events compared with general population. Indoxyl sulfate (IS) is a potent uremic toxin associated with the appearance of cardiovascular disease prevalence. However, mechanism underlying IS association with thromboembolic events is not fully understood.
Material and methods: We evaluated the effect of IS on thrombotic process after acute treatment in electrical current-induced arterial thrombosis in Wistar male rats. IS doses: 3, 10, and 30 mg/kg of body weight were administered intravenously. We assessed IS influence on parameters of coagulation, fibrinolysis, collagen-induced platelet aggregation and blood morphology.