Michael F Michelis
Lenox Hill Hospital, USA
Title: New approaches to preventing progressive renal function loss
Biography
Biography: Michael F Michelis
Abstract
A variety of therapeutic interventions are available to alter the abnormalities seen in patients with chronic kidney disease (CKD). Programs can now be developed to slow the progression of CKD. This delay can be achieved by using accepted recommendations for optimal diabetes therapy (HbA1c target 7%), goals for blood pressure levels, reduction of proteinuria and the proper use of ACE/ARB therapies. For example, limits on dietary sodium and protein intake and reduction of body weight will be decrease proteinuria. Proper treatment for elevated serum phosphorus and parathyroid hormone levels as well as therapy for dyslipidemias and anemia can mitigate renal loss. Other less widely appreciated measurable abnormalities such as elevated FGF-23 levels, hyperuricemia and metabolic acidosis have more recently been recognized to be associated with progressive renal insufficiency. Efforts aimed at correction of these disorders may have an important role in altering the course of renal dysfunction. Data will be presented to support this strategy.