Yoshihide Ogawa
Tokyo-West Tokushukai Hospital, Japan
Title: Restored kidney transplantation using kidneys nephrectomized for small renal tumor: Lessons learned from clinical trials to date
Biography
Biography: Yoshihide Ogawa
Abstract
The organ donor shortage is a serious problem in Japan and leads to an increase in transplant tourism to Asian countries. Restored kidneys after nephrectomy for small renal tumor (low-risk of cancer transmission) have been considered as a source for potentially solving the problem. Approximately 100 cases as such were collected by Yu. We are performing two prospective clinical trials that utilize restored kidneys after resection of renal tumors for transplanting into unrelated (20 cases estimated) and related recipients (5 cases).
Twelve unrelated patients and four related donors donated kidneys with renal tumors (14 RCCs and 2 AMLs). The kidney nephrectomized was restored and transplanted into unrelated and related recipients. Unrelated transplant was performed in 12 patients including 4 with transplant history, and related transplant in 4 patients (ABO-incompatible in 2). Ten recipients experienced rejection episodes and the latest serum creatinine levels ranged from 1.10 to 3.19 mg/dl at 2 months to 6 years after transplant. One returned to dialysis, one unrelated recipient died of infection and uremia at 5 months and another related recipient died of unknown cause with functioning graft at 2 months. Four restored kidneys from donors over 70 years old are functioning well. There is no RCC recurrence in the recipients so far.
In conclusion, selected candidates can benefit from restored kidney transplant, achieving good renal function without recurrence of RCC.