Elayne Ooi
Hollywood Private Hospital Perth, Australia
Title: Outcomes of SpaceOAR Hydrogel when used as rectal protection prior to prostate radiotherapy
Biography
Biography: Elayne Ooi
Abstract
SpaceOAR Space Organ At Risk is an absorbable injectable hydrogel which creates a temporary barrier between the prostate and rectum. It is used in patients undergoing local radiotherapy for prostate cancer. Traditionally, the dose-limiting factor for brachytherapy has been the rectum - due to the sensitive rectal mucosas close anatomical proximity to the prostate.
After being injected into the peri-rectal potential space under rectal ultra-sound guidance, SpaceOAR creates a hydrogel barrier pushing the rectum out of the way and forming a physical barrier. Clinically, this translates into reducing rectal radiation, rates of rectal toxicity and potentially allowing for an increased radiation dose to the posterior aspect of the prostate.
Made of polyethylene glycol, the hydrogel is formed when the accelerator and precursor are combined. Once injected into the peri-rectal space, it is immediately effective and remains so for 3 months. Over the space of 6 months, it is slowly absorbed and excreted by the kidneys.
Twenty-three patients with T1-T2 prostate cancer underwent spaceOAR insertion between 2014-2017 prior to prostate external beam radiotherapy. We will be presenting the short-term outcomes of SpaceOAR in this pilot study.