Thi Tuong Vy Vo
Medical Nephrologist with expertise in Paediatric Nephrology
Title: CMV INFECTION IN CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATEOUS: DESCRIPTION OF 3 CASES
Biography
Biography: Thi Tuong Vy Vo
Abstract
Background: systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can involve many organs. In patients with SLE, there is an association of immunodysfunction due to the disease itself and immunocompromised conditions due to the use of immunosuppressive medications that put the patients susceptible to opportunistic infections. Cytomegalovirus (CMV), has been recognized in recent years to have multi-organ involvement in SLE patients. However, the screening and treatment for CMV infection in SLE patients has not been appropriately done. Cases: we reported herein three cases of severe CMV disease in pediatric SLE patients. CMV infection was detected after SLE diagnosis, all were female from 12 to 16 years old, gastro-intestinal manifestations in two patients, proliferative nephritis in two, fever and hematologic manifestations in all patients. All patients presented a high viral load in the blood while tissue CMV found in two of three: cerebro-spinal fluid and bone marrow. Two patients received ganciclovir who fully recovered but one patient died with active CMV infection without antiviral treatment. Conclusions: This is the first report on CMV disease in SLE patients in Viet Nam, having changed our look in the management of infectious problem for these patients.