Diabetic kidney disease (DKD) is a time progressive problem give rise in uncontrolled Diabetics increasing risks for CKDrnand /or ESRD. Th e vulnerability to renal dysfunction manifested with sudden glomerular hyperfi ltration associated withrnmicro-to macroalbuminuria passing to renal failure. So that, screening of specifi c enzymes shift s or urinary albumin may predictrnonset diabetic nephropathy. Our study aimed to assessment of urinary alkaline phosphatase (ALP), alanine aminopeptidasern(AAP), acid phosphatase (ACP) and microalbuminuria of 100 diabetic patients compared to 51 healthy volunteers of matchedrnage and sex in Al-Lieth area. Mean values of measured biomarkers in patient group for ALP, AAP, ACP, Cr and MAU were 17.2rnU/L, 14.3 U/L, 426.4 U/L, 86.3 mg/L and 28.6 mg/dl VS in control group were 8.7 U/L, 5.9 U/L, 188.5 U/L,161.6 mg/dl and12.1rnmg/L respectively. Despite of signifi cant comparisons between markers ratio means in patients with control groups (p≤0.001)rnfor genders, 49% of diabetics suff ered from microalbuminuria and 60.66% with raised enzyme levels. Additionally, signifi cantrnpositive correlations were found between enzyme markers with BMI (p≤0.01) and DM durations with blood pressure (p≤0.01).rnWe concluded that using urinary enzyme levels could be benefi cial none-invasive indicators for renal deterioration in type IIrndiabetics.rnIn conclusion, these markers and their ratios may be used as noninvasive early indicators for renal deterioration in DM typernII patients.
