Nephrology & Therapeutics

Kidney glomerulus podocyte

Podocytes are cells in the Bowman's capsule in the kidneys that covering around capillaries of the glomerulus. ... The Bowman's capsule filters the blood, retaining large molecules such as proteins although smaller molecules such as water, salts, and sugars are filtered as the first step in the formation of urine.

 Knowledge of glomerular podocyte   biology is ration to advance our sympathetic of the science and mechanics of the glomerular filtering process, opening the way to a variety of new potential applications for clinical targeting

The pathogenesis of proteinuria in nephrotic syndrome has been linked to mechanical pathways in the renal glomerulus that involve the function of the podocyte epithelial cells. Patients with nephritic syndrome demonstrate a distinct disease-pheno type association that involves foot process effacement or the spreading of podocyte foot processes; however, the details of the association remain unclear. Podocyte biology is a developing science that promises to help recover our understanding of the mechanistic nature of multiple diseases associated with proteinuria in nephrotic syndrome. Here, we provide an overview of monocyte biology, highlighting some recent developments and classifying areas for future study. It is the first of a series of articles summarizing presentations and discussions from a roundtable discussion focused on the management of proteinuria in nephrotic syndrome