Tubulointerstitial Diseases


Tubulointerstitial nephritis (TIN) may be a frequent explanation for acute kidney injury (AKI) which will cause chronic kidney disease (CKD). TIN is related to an immune-mediated infiltration of the kidney interstitium by inflammatory cells, which can reach fibrosis. The foremost common explanation for acute tubulointerstitial nephritis is an allergy to a drug. Antibiotics like penicillin and therefore the sulfonamides, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs)—including aspirin—may trigger an allergy.


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